The Tosoh Bioscience laboratories recently completed a series of experiments to determine the oligonucleotide dynamic binding capacities for Toyopearl and TSK-GEL anion exchange resins. The resin selection table below presents the data obtained from these experiments using a 20-mer oligonucleotide with the sequence 5’-GAA TTC ATC GGT TCA GAG AC-3’.

Please note that the TSK-GEL SuperQ-5PW bulk resins are available in 20 and 30µm particle sizes to provide superior resolution performance for your “n-1” purifications. Click here to go to our new Tosoh Bioscience 2010-2011 catalog (see page 17) showing these and other properties of TSK-GEL SuperQ-5PW resins. (May require registration to our website)

Toyopearl SuperQ-650M resins have the highest capacity shown due to lower crosslinking than the corresponding TSK-GEL resins. This lower percentage of crosslinking leaves a higher number of ligand attachment sites available for increased binding capacity.

Oligonucleotide Resin Selection Table

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