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GE Healthcare


Discover how MicroCal™ Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) systems can improve formulation development in your organization.

With ITC and DSC you can:

Protein-based vaccines
There is a growing interest in the development of vaccines using proteins, both native and recombinant. A key factor in the formulation of such vaccines is the selection of excipients at optimal concentrations to provide extended shelf life while maintaining safety.

Microcalorimetry
Microcalorimetry is increasingly utilized to explore protein-excipient interactions in the design and optimization of biotherapeutic formulations. The same technology can be applied to protein-based vaccines.

ITC and DSC
Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) reveal important mechanistic information regarding interactions such as drug-excipient binding and protein unfolding in the presence of excipients, providing valuable insights into the development of optimal formulations.
  • Understand the mechanism(s) of protein-excipient interactions
  • Improve the stability of a protein-based vaccine during storage
  • Quickly provide critical information in developing
    the optimal formulation

Download a NEW Application Note to learn more:
Applications of Isothermal Titration Calorimetry and Differential Scanning Calorimetry in Biopharmaceutical Formulation Development
by J. M. Woods, M. Puri, D. Doucet, T. Derrick,
S. Morar-Mitrica and D. Nesta of GlaxoSmithKline

This application note presents two case studies. The first utilized ITC to assess the interactions between a surfactant and a protein. The second case study, using both DSC and ITC, revealed that the structural integrity of the protein was best maintained at a particular pH in the presence of an antimicrobial agent.

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