| As upstream
expression increases bioreactor titers, downstream WFI water usage
increases proportionally. This places increased throughput pressure
on downstream’s existing plant tankage for buffer prep, buffer
storage, and in-process product hold steps.
TOYOPEARL GigaCap®
CM-650M resin reduces target elution volumes up to 75%. By maintaining
its 100 g mAb/L dynamic binding capacity in loading conductivities
up to 11 mS/cm (pH 4.7), TOYOPEARL GigaCap CM-650M resin can also
minimize the amount of water needed for feedstock dilution.
The bottom line
is that TOYOPEARL
GigaCap CM-650M resin, when placed early in the chromatographic
purification train, can reduce the amount of WFI water used in subsequent
manufacturing steps.
Buffer conductivity effect on TOYOPEARL GigaCap CM-650M capacity
(polyclonal h-IgG):
Feel free to
email
me if you have any questions or would like to request a sample.
Cordially,
Al Jackewitz
Biopurification Market Manager
Tosoh Bioscience
and TOYOPEARL GigaCap are registered trademarks of Tosoh Corporation.
|
