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| NEW Featured Series: |
BioPharm International provides weekly articles and podcasts on best practices for moving products from discovery to development. Featuring expertise from the global biotech industry. Learn more with BioPharm's Drug Development Basic Training series today.
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| Featured Webcast: |
Challenges and Opportunities in Biopharmaceutical Higher Order Structure and Conformation Stability Analysis: A Focus on HDX Applications
Event Date: March 27, 2012 at 11:00 AM EDT
Regulators are encouraging the biopharmaceutical industry to improve biophysical characterization of protein therapeutics when performing drug safety evaluations. This is especially important for higher order structure integrity, conformation stability, and epitope mapping, all crucial steps for therapeutic antibody characterization. However, previously there was no widely available, high-resolution analytical method to characterize protein therapeutics in solutions. Hydrogen/deuterium-exchange mass spectrometry (HDX-MS) has become increasingly popular with academia investigating protein dynamics, as well as protein-ligand and protein-protein interactions. Recent development of automation and data-extraction software enables the application of HDX-MS to protein characterization in the biopharmaceutical industry. Several companies have used or are considering using HDX-MS data for their regulatory agency filings. This webinar will detail the fundamentals of HDX-MS and its application to biopharmaceutical development.
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| Featured Podcasts: |
MicroRNA Drug Delivery
Balkrishnen Bhat, senior director and head of chemistry at Regulus, discusses core technology in microRNA drug delivery (Posted November 2011).
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Biotech Outsourcing Strategies
Balkrishnen Bhat, senior director and head of chemistry at Regulus, discusses the company's outsourcing strategies. (Posted November 2011).
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Cell-free Protein Expression
Dr. Trevor Hallam, chief scientific officer at Sutro Biopharma, discusses a nontraditional approach for expressing therapeutic proteins and peptides. (Posted November 2011).
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| Featured Whitepapers: |
High-Resolution, Fast MAb Charge Variant Analysis
These new Thermo Scientific MAbPac SCX small particle phase columns were developed for high resolution separations wand orthogonal selectivity for MAb charge variant characterization. Separations using these columns on the bio-inert Thermo Scientific Dionex UltiMate 3000 Titanium LC System revealed high-resolution, fast analysis of MAb variants.
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Advertiser: Thermo Fisher Scientific
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Structural Characterization of Monoclonal Antibodies
A number of new monoclonal antibody products and monoclonal antibody biosimilars are in development, all require extensive characterization to obtain the necessary approvals for clinical trials and eventually marketing approval.
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Advertiser: SGS Life Science Services
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| Featured Microsite: |
Highly useful bioprocess information online
Introducing a new BioPharm International web site featuring practical tips and technical insights for the entire process development spectrum. Check out these latest fresh topics:
Articles/App Notes: Column efficiency testing
Practical Tips: Western blotting principles
Posters: Host Cell Protein ELISA assays
Multimedia Video: High-throughput process development
Webcasts: Automated HTPD technology
Increase your process development IQ today!
Visit http://www.processdevelopmentforum.com
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Sponsored by: GE Healthcare
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