CASE STUDY: In-house Mass Spectrometry Becomes Essential in Supporting Research and Process Development

The Company Macrogenics, Inc., a clinical-stage biopharmaceutical company
The Challenge Macrogenics had numerous programs that were rapidly moving towards the clinic and wanted to routinely review mass spectrometry data. However, full MS analysis outsourced to its CRO was taking too long and costing too much.
The Solution Macrogenics brought MS capabilities in-house for confirmation and characterization of its biotherapeutic candidates.
The Results

Accelerated analytical turnaround times

  • Top-down intact mass analysis from
    1-3 weeks to 2-3 days
  • Bottom-up peptide mapping studies from 3-6 weeks to about 1 week

Eliminated high-cost outsourcing of mass spectrometry analyses

  • $400 per sample for outsourced top-down MS analysis
  • $3,000 per sample for outsourced
    LC-MS peptide mapping studies
Read the full case study

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Waters Biopharmaceutical Team

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