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| LIVE WEBCAST |
Wednesday, September 19, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
Can't make the live webcast? Register now and view it on-demand after the air date. |
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| Event Overview |
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| Downstream process chromatography scientists are constantly searching for more selective and improved ways to remove aggregates and other process-related impurities from a monoclonal antibody (mAb). Among numerous available separation modes, mixed-mode chromatography is a unique and powerful tool for purifying mAbs. |
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| Hydroxyapatite is a mixed-mode chromatography media that has proven to be useful as a purification medium for biomolecules such as monoclonal antibodies and their aggregates. The highly selective and robust nature of hydroxyapatite can effectively remove dimer and higher order aggregates from a purified mAb sample. Hydroxyapatite has unique separation properties for biomolecules and under optimum conditions offers unparalleled selectivity and resolution for process scale operations. |
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| This presentation reviews the purification of a monoclonal antibody and the removal of its aggregates, showcasing a newly developed method using potassium salts. |
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| Key Learning Objectives
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Discover a new method for operating hydroxyapatite media for the removal of mAb aggregates to as low as ~1% |
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Understand how hydroxyapatite chromatography can provide an effective means of removal of mAb aggregates without jeopardizing the yield or purity of the mAb |
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Learn how to select the appropriate conditions to make the most effective use of hydroxyapatite chromatography in mAb and aggregate separations |
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| Who Should Attend |
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| Chromatographers, method developers, and process engineers who are involved with the development of downstream purification processes that include steps for aggregate removal |
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| Presenters |
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| Bill Evans |
| Process Chromatography Technical Specialist |
| Tosoh Bioscience |
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| Kevin O’Donnell, PhD |
| Process Chromatography Support Manager |
| Tosoh Bioscience |
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| Moderator |
| Rita Peters |
| Editorial Director |
| BioPharm International |
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Sponsored by:
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Presented by:
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| Have any questions? Contact Ethan Castillo at ethan.castillo@ubm.com |
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