Aptima^® HPV Assay Performance:
Correlation Between Detection of Human Papillomavirus E6/E7 mRNA and Clinically Relevant Cervical Disease Detection

Approximately 80% of sexually active women will become infected with one or more HPV types in their lifetime. In cells that are infected, HPV DNA either can remain in episomal form or can integrate into the cell genome, which often (but not always) results in the expression of HPV E6 and E7 mRNA and proteins. Detection of the presence of E6/E7 mRNA indicates that the infection has become more biologically and likely clinically "active," and is therefore potentially oncogenic.

This special supplement to the January 2014 issue of Contemporary OB/GYN discusses the biology and disease progression of HPV infection and explains the technologically unique mechanism of the clinically validated, FDA-approved Aptima HPV assay which detects E6/E7 mRNA from the 14 most oncogenic HPV variants.