In both HPLC and GC, you do what you can to keep retention times within the limits established by your method. Column ageing, temperature variations, even operator effects can combine to cause drift in retention times that can move a peak from the expected position. Making changes to the instrument settings, such as activating electronic pressure control, doesn’t help with the previous runs.

There is a software solution that enables you to correct retention times automatically and immediately post-run -- LineUp^™ from InfoMetrix^®. Using technology borrowed from voice recognition systems, chromatographic traces can be recast to closely align with an application-specific run. This ensures that your chromatograms will have their peaks positioned consistently from run-to-run, from month-to-month, and even from instrument-to-instrument. And LineUp does not rely on retention marker peaks, nor does it require a constant population of analytes in the sample.

• The LineUp approach works with any source of chromatographic data
• Automation is incorporated for most of the major instrument software systems
• Historical data can be brought into alignment with the current chromatographic procedure

Click here http://infometrix.com/software/products/lineup/ to see LineUp applications in process and laboratory settings and to see how the software is used in the petrochemical, pharmaceutical and food industries. To learn more about how LineUp technology has been deployed over the last 10 years, we have references listed on the web site.

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