In this study, a simple method based on recovery is assessed for the detection of matrix effects. Two alternative methods for the rectification of matrix effects in LC–MS are also assessed: standard addition and the coeluting internal standard method.
This article describes a number of popular myths or half-truths in UHPLC and provides data that contradict or even repudiate some of these commonly held beliefs.
As applied to natural products research, mass spectrometry is fraught with challenges and pitfalls. This article provides an account of strategies to conduct effective research despite these obstacles.
March 2014
