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A SPECIAL
ANNOUNCEMENT FROM:
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Simultaneous in vivo Quantification and Metabolite Identification of Plasma Samples Using High Resolution QTof and Routine MSE Data Analysis
 This application note summarizes the collaboration between Vertex Pharmaceuticals and Waters Corporation to test and demonstrate a quan/qual DMPK workflow to determine robustness and reliability of QTof measurements compared to triple quadrupole MS. Here, propranolol was used as a model compound and a pharmacokinetic (PK) rat study (containing standard curves, PK runs, and QCs) was conducted using a Xevo G2 QTof MS System. The sample set was also run using a triple quadrupole platform with a typical MRM-based workflow under the same chromatographic conditions to provide a reference comparison data set.
Waters Chemical Analysis Team
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Waters, ACQUITY, Advanced Polymer Chromatography, APC, ACQUITY APC and
The Science of What's Possible are trademarks of Waters Corporation.
Waters Corporation,
34 Maple Street, Milford, MA, 01757 USA
www.waters.com |
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