In this interview with Bethany Degg of The Column, Mangelings discusses the importance of chiral chromatography in pharmaceutical analysis, the challenges of current methods, and where the field is heading next.
The goals in ultrahigh-pressure liquid chromatography (UHPLC) method development are to first find the best separation, second find the best column, and third find the most robust method in a multifactorial Design Space. Trial and error methods are not sufficient anymore and solid science based on Quality by Design (QbD) principles is required.
The mobile phase is an essential and integral part of an analytical system and influences the success of the analysis and the quality of the data and results.
The process of developing different methods can be a tricky, time-consuming process. Ade Kujore from Cecil Instruments Limited, Cambridge, UK, summarizes many of the issues that should be addressed throughout the method development process.
Analysis of VOCs in earwax, optimizing biopharmaceutical immunogenecity assays using LC–MS–MS, identification of four new ozone depleting gases in the atmosphere, and the latest news in brief are featured.
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8 April 2014
