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Webster's New Collegiate Dictionary defines a myth as "an ill-founded belief held uncritically, especially by an interested group." Could that group be misinformed chromatographers? This installment of "Column Watch" will look at the top 10 high performance liquid chromatography (HPLC) column myths and attempt to demystify them by presenting some evidence that they are untrue. Since ultrahigh-pressure liquid chromatography (UHPLC) has come about, new myths are popping up and these shall also be dealt with here.
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