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HPLC - Troubleshooting Changes in Selectivity Retention & Resolution |
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Everything about your chromatogram has changed and you just don’t know why. The peaks have different retention times, peaks that are normally well resolved are now co-eluting, and the selectivity of all of the peaks has been altered. Taking one of these problems at a time is challenging, let alone all three! However, help is at hand... |
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GC - Troubleshooting Broad Peaks and Loss of MS Sensitivity |
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A GC-MS method which normally works well starts to exhibit broad peaks and there is a loss in sensitivity, what could possibly be causing the problem? Column contamination, an air leak, incorrect oven temperature, the list could be lengthy... |
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HPLC - Troubleshooting Cycling Baselines and Pressure Fluctuations |
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Problematic baselines. Pressure fluctuations. It’s a nightmare that a lot of chromatographers have faced. Using the CHROMacademy HPLC troubleshooter we have solved this exact problem in the simple steps. Keep reading to find out how... |
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GC Troubleshooting Guide to Broad Split Peaks |
GC Troubleshooting Guide to Peak Area Reproducibility |
HPLC Troubleshooting Guide to Split Peaks |
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Broad and split peaks might possibly be one of the most common problems that a chromatographer will see... |
There are a number of factors that could be the cause including poor column positioning, backflash, or incorrect inlet temperature... |
We explore possible causes of split peaks, how to solve this common problem, and how to try to avoid it in the future... |
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