16 December 2015 Issue

Look inside for practical advice on separation science and thought–provoking commentary.

The 2015 Instrumental Innovations

Selected highlights of innovative chromatography products.

The benefits of TOF-HRMS in bioanalysis

The benefits of time-of-flight high resolution mass spectrometry (TOF-HRMS) are discussed.

Finding the right calibration standards in GPC/SEC

In the latest instalment of Tips and Tricks some general points that should be considered when determining calibration standards are discussed.

The power of planar chromatography

High-performance thin-layer chromatography (HPTLC) offers many advantages over conventional separation techniques when applied to complex samples. The Column interviewed Gertrud Morlock from Justus Liebig University Giessen in Germany, on her current research, which involves hyphenating HPTLC with multiple analytical techniques.

Improving UHPLC method performance

Simple method development rules using new column technologies are presented that demonstrate improved accuracy for an UHPLC method.

Trends in bioanalysis using LC–MS–MS

This article explores the limitations of LC–MS–MS for bioanalysis of biologics and some of the latest trends for overcoming these in bioanalysis laboratories.

News update: Quantifying ocular besifloxacin using LC–MS–MS

Quantifying ocular besifloxacin using LC–MS–MS, bioaccumulation of pharmaceuticals with GC–MS, and the latest news in brief are featured.