Metabolomics provides an instant snapshot of cellular process and therefore is increasingly being used to identify biomarkers in cancer research. Metabolomic studies have shown that the disease state can disrupt the energy cycles, however the analysis of these small polar metabolites can be challenging.

 

Ion chromatography coupled with high resolution accurate mass spectrometry (IC-HR/AM) using Orbitrap™ MS technology provides the solution to many of the analytical challenges needed to differentiate isobaric metabolites.