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| Dear {{contact.firstname}}, Thank you for registering for LCGC's July 19th webcast, "Orthogonal Chromatographic Techniques for the Quantitative Analysis of Potential Mutagenic Impurities." |
| If you'd like to learn more about this topic, the following information may be of interest to you. |
| Analysis of Genotoxic Impurities of Imatinib Mesylate by LC-MS from Early Development to Routine Monitoring This application note describes a sensitive and rapid UPLC method coupled with mass detection for the quantitative determination of two genotoxic impurities (GTI) of imatinib mesylate, an anti-neoplastic (anti-cancer) drug used in the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors. Two of its process impurities are classified as potential GTIs and must be monitored during the synthesis process.  Coupling Mass Detection with UV to Improve Method Sensitivity for Esters of Benzenesulfonic Acid in Analysis of Genotoxic Impurities This technology brief demonstrates the use of an ACQUITY® QDa® Mass Detector integrated with an ACQUITY Diverter Valve for the analysis of aryl esters of p-toluenesulfonic acid in monitoring of potential genotoxic impurities.  |
For additional content on impurities analysis, visit impurities.waters.com.
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