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Polar Compound Retention
Understanding What Works and What Doesn’t Work In Reversed-Phase Polar Compound Retention
Tuesday, July 25, 2017
1:30 pm - 2:30 pm ET
(12:30pm CT, 11:30am MT, 10:30am PT)
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Presenter: Kevin Jenkins
Product Manager, HPLC Columns
Waters Corporation, Milford, MA USA |
Join us for this free and informative live webinar!
One of the most difficult challenges confronting chromatographers is the retention and separation of highly polar water-soluble organic compounds. Unfortunately, many chromatographers do not understand the reasons for poor polar compound retention. Presented in this seminar is a practical explanation of stationary phase chemistry and its role in polar compound retention. Building upon this basic understanding, a description is provided that explains how a stationary phase can provide enhanced polar compound retention and longer column lifetimes in reversed-phase separations. Finally, we will learn about how particle substrate and stationary phase research can provide similar performance benefits in Ultra Performance LC separations.
Specific topics include:
- Chromatographic techniques that have been used to retain, separate and detect polar, water-soluble organic compounds
- What hydrophobic collapse really is (and more importantly, what it is not)
- An explanation of why embedded polar group stationary phases actually cause less retention for polar compounds in reversed-phase HPLC
- How an intelligently designed C18 stationary phase can retain polar compounds while thriving in acidic, highly aqueous mobile phases
- Examples of how bonded phase research along with particle morphology manipulation can offer improved UPLC and UHPLC separations
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Can't make it? Still register and you'll be able to watch it on demand afterwards.
For questions or comments, please send an email directly to me by clicking on my name below.
Sincerely,
Susan Harris
Waters Corporation USA
P.S. Dont forget to view our past recorded webinars! Click here for a full list. |
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