20 June 2017 Issue

Look inside for practical advice on separation science and thought–provoking commentary.

Unravelling the mysteries of glycosylation using MRM and UHPLC–MS

A novel quantitative method combining multiple reaction monitoring (MRM) and ultrahigh‑pressure liquid chromatography coupled to mass spectrometry (UHPLC–MS) has been developed by Carlito Lebrilla and his team to study site-specific glycosylation in manufactured recombinant monoclonal antibody drugs (rmAbs). He spoke to The Column about this work.

Mistakes with matrix effects in blood alcohol tests

The role of MS in host cell protein analysis

Some of the current methods for HCP detection are considered, with a particular focus on MS.

DLS: A high-throughput biotherapeutic screening technique

DLS constitutes a high-throughput biophysical screening technique for early-stage assessment of candidate developability and optimal formulation conditions. This article explains more.

News update: The latest research and company news

MS in biopharmaceutical development

The developments in the use of MS for biopharmaceutical development, manufacturing and QC, and some of the key pieces that must fall into place before MS-based methodologies can be more widely adopted within regulated (GxP) laboratories are discussed.

20 June 2017 Issue

Look inside for practical advice on separation science and thought–provoking commentary.

Unravelling the mysteries of glycosylation using MRM and UHPLC–MS

The role of MS in host cell protein analysis

DLS: A high-throughput biotherapeutic screening technique

MS in biopharmaceutical development

The challenges of drug-to-antibody measurement

Charge variant profiling of biopharmaceuticals

News update: The latest news