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In our October issue:

COLUMNS

Column Watch
Highlights from the HPLC 2018 Symposium
David S. Bell, Cory E. Muraco, and Connor Flannery
Topics that stood out at HPLC 2018 include advances in large-molecule separations, multidimensional separations, 3D printing, chiral separations, and HILIC. Also, many speakers addressed separation fundamentals, including ways to increase speed, generate higher throughput, and add selectivity.

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LC Troubleshooting
Mixing and Mixers in Liquid Chromatography—Why, When, and How Much? Part I, The Pump
Dwight R. Stoll
Many LC users are unclear what happens when we combine two (or more) flow streams in LC systems, and when mixers are needed to blend the fluids. This discussion explains why mixers are needed, and when and how you might consider using something other than the default mixer setting.

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Pi18081 – Lab Week
Designed to maximize your time out of the office, IVT's Lab Week conference provides the value of three conferences in one, allowing your entire team to select sessions that best meet business objectives in laboratory data integrity, analytical procedures & methods validation and stability testing. Join 100+ of your industry peers for 3 days of workshops, think tanks, interactive presentations, case studies and educational courses. Learn more
Perspectives in Modern HPLC
Modern Trends and Best Practices in Mobile-Phase Selection in Reversed-Phase Chromatography
Michael W. Dong and Barry E. Boyes
Modern trends in LC mobile-phase selection and preparation include using simpler mobile phases, increased use of MS-compatible mobile phases, and eliminating filtration and certain mobile-phase additives. Here, we discuss those and other trends and best practices, as well as the fundamentals behind them.

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Exclusive Interview from ASMS 2018
Part 1: Imagine. Pioneer. Transform.
Build Your Legacy – Biopharma
Watch the Video
Focus on Food Analysis
The Quest for Greener Sample Preparation in Food Analysis
Laura Bush
Elena Ibañez is determined to make sample preparation for food analysis not only more environmentally friendly but also more efficient, as she explores approaches that simplify solvent selection, increase solvent selectivity, and lessen the role of chemical solvents.

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The Essentials
Tips for Successful GC–MS Tuning and Optimization
Proper tuning and calibration of instruments ensure their peak response and an exact mass-to-charge ratio and ion abundance measurement.
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PEER-REVIEWED ARTICLE

Molecular Imprinting for Sample Preparation
Dimitrios Bitas and Victoria Samanidou
Molecularly imprinted polymers can replace conventional sorbent materials in sample preparation techniques such as solid-phase extraction (SPE), solid-phase microextraction (SMPE), and matrix solid-phase dispersion (MSPD), offering increased selectivity over the target analytes.

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LIVE WEBCASTS
N-Glycan Sample Preparation and Analysis Workflows for Screening and Characterization of Biotherapeutics
North America: Wednesday, October 31, 2018 at 11am EDT | 10am CDT | 8am PDT
Europe: Thursday, November 1, 2018 at 9am GMT | 10am CET
Asia Pacific: Friday, November 2, 2018 at 8:30am IST | 11am CST | 12pm JST
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Editors' Series: GC×GC–TOF-MS in Food and Feed Control: Going Beyond Dioxin Measurements
Friday, October 26, at 11am EDT| 8am PDT| 4pm BST| 5pm CEST
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Challenges in Extracting Perfluorinated Compounds in Drinking and Waste Waters
Thursday, October 25, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Rapid Automated Peptide Mapping
Wednesday, October 24, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Fast, Sensitive, and Robust PBDE Analysis in Food
Tuesday, October 23, 2018 at 11am EDT/ 8am PDT/ 4pm BST/ 5pm CEST
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LIVE WEBCASTS
Environmental and Agricultural Applications of CESI-MS: Overcoming the Challenges of Quantifying Highly Polar Amines
Europe Broadcast: Friday, Oct. 19, 2018 at 3 pm BST | 4pm CEST
US Broadcast: Friday, Oct. 19, 2018 at 2 pm EDT | 1 pm CDT | 11 am PDT
Asia Pacific Broadcast: Monday, Oct. 22, 2018 at 11 am CST | 12 pm JST | 1 pm AEST
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Improved Protein/Variant Recovery, Selectivity, and Reproducibility with New Monosized WCX Particle Technology
Thursday, Nov. 1, 2018 at 11 am EDT | 8 am PDT | 3 pm GMT | 4 pm CET
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Expanding the Limits of Single-shot Proteomics Using Micro Pillar Array Columns and Data-Independent Acquisition (DIA) Methods
Monday, Nov. 5, 2018 at 9 am EST | 2 pm GMT | 3 pm CET
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Enhanced Environmental Monitoring, Part 2: Five High-Throughput Lab Applications of Direct MS
Wednesday, Nov. 7, 2018 at 11 am EST | 8 am PST | 4 pm GMT | 5 pm CET
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Addressing the Analytical Challenges of Reversed-Phase Characterization of Protein Therapeutics
Friday, Nov. 9, 2018 at 11am EST | 8am PST | 4pm GMT | 5pm CEST
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Enhanced Environmental Monitoring, Part 3: Direct MS for Demanding Air Quality Applications
Monday, Nov. 19, 2018 at 11am EST | 8 am PST | 4 pm GMT | 5 pm CET
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If you would like to submit an article to LCGC, contact Laura Bush, Editorial Director - laura.bush@ubm.com

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