Figure 1A. Fundus photographs showing subtle pigmentary change temporal to fovea.
Figure 1B. Fundus autofluoresence showing hyperautofluorescence temporal to fovea; more evidence in the left eye.
Figure 1C. Choroidal thickness over 213 μm is fairly normal for the area measured. Localized outer segment atrophy marked by blue ovals. ILM drape in the left eye noted by red arrow.
Figure 1D. Hyperfluorescence temporal to fovea in 1E late phase of FA is not consistent with leakage caused by CNVs. Few areas of drusen staining noted. Example marked by arrow.
Figure 1E. OD: OCT shows full-thickness macular hole with complete separation of the posterior vitreous cortex (blue arrow), additionally alteration of the outer-retina is noted only in the pre-foveal region. OS: Foveal outer segment atrophy particularly in the typical temporal location and draped ILM are among notable findings.
Figure 2A. Fundus photograph demonstrating subtle parafoveal retinal pigmentary changes.
Figure 2B. Areas of autofluorescence associated with altered RPE OU.
Figure 2C. (A) Non-enhanced depth (EDI) scan of the right eye at the time of the first visit shows the macula serous detachment while, image of the left eye (B) demonstrated the PED. A later DEDI scan of the right eye following photodynamic therapy shows resolved serous fluid. Additionally with this image the choroid thickness in the foveal area measures at 502 μm.
Figure 2D. Foci of hyperfluorescence noted in both eyes demonstrating damaged RPE. Subtle hypofluorescence due to chronic subretinal fluid is noted in the macula of the right eye.
Figure 3A. Small drusen seen in color photograph, fundus autofluorescence and white-on-black OCT scan.
Figure 3B. Intermediate drusen black on white OCT
Figure 3C. Large drusen.
Figure 4. Drusen staining in fluorescein angiography.
Figure 5. (A) FAF demonstrating hperautofluorescence, (B) OCT shoeing alteration of the RPE, (C) FA showing broad staining.
Figure 6. Variety of states of altered RPE is noted here. (A and C) Clinically GA marked with the circle appears yellowish-white and featureless, and has a "absolute" hypoautofluorescence. (E) On OCT, GA not only shows the absence of RPE but intense hyperreflectivity is witnessed immediately below the bruch's membrane. PEDs are noted on OCTs images F, G and H and various areas of elevated RPE. Hyperpigmentation and pigmentary migration to the intraretinal space is noted by arrow in B and H.
Figure 6. Variety of states of altered RPE is noted here. (A and C) Clinically GA marked with the circle appears yellowish-white and featureless, and has a "absolute" hypoautofluorescence. (E) On OCT, GA not only shows the absence of RPE but intense hyperreflectivity is witnessed immediately below the bruch's membrane. PEDs are noted on OCTs images F, G and H and various areas of elevated RPE. Hyperpigmentation and pigmentary migration to the intraretinal space is noted by arrow in B and H.
Figure 6. Variety of states of altered RPE is noted here. (A and C) Clinically GA marked with the circle appears yellowish-white and featureless, and has a "absolute" hypoautofluorescence. (E) On OCT, GA not only shows the absence of RPE but intense hyperreflectivity is witnessed immediately below the bruch's membrane. PEDs are noted on OCTs images F, G and H and various areas of elevated RPE. Hyperpigmentation and pigmentary migration to the intraretinal space is noted by arrow in B and H.