Potency Determination by qNMR
|
|
For
more than two decades, scientists have been using NMR for quantitative
purposes and had established useful practical methods. Recently, the use
of quantitative NMR (qNMR) has been shown to be a single point
replacement for routine early development testing which previously
combined elements of identity testing, chromatography assay, moisture
analysis, residual solvent analysis, and elemental analysis [”Webster
et al, Anal Chem, 86, 11474 (2014)”]. Compared to HPLC, qNMR is faster
and more straightforward with lower method development costs for a new
analyte. In line with the growing interest in qNMR, the Japanese
pharmacopeia recommends the use of qNMR to determine the purity of
substances that will be used as reference material by HPLC and other
techniques.
In this webinar, Fabrice Moriaud, Ph.D. and Anna
Codina, Ph.D from Bruker Biospin will present automatic workflows for
qNMR (with internal and external standard) which are streamlined from
sample submission to report, making them ideal solutions for both
experts and non-experts. They will outline Bruker’s new PotencyMR, a
fully automated, cost-effective internal standard solution for
determining the potency of drugs. They will show examples of potency
determination of APIs and of formulated material containing a
significant percentage of excipients. The workflow also allows running
samples with previously defined integration regions, which opens
potential applications in the quality control arena.
See you On Line!
Your Bruker Webinar team
|
|
|
When and Where
|
|
June 20, 2017 - 10:00am Berlin Time, 04:00 Beijing Time
|
|
|
|
June 20, 2017 - 11:00am Boston Time, 05:00pm Berlin Time
|
|
|
 |
Anna Codina, Ph.D. (Biography), Product Portfolio Manager, Pharma Market - Bruker UK Limited, Coventry, U.K. Fabrice Moriaud, Ph.D. (Biography), Product Manager PotencyMR - Fällanden, Switzerland |
|
|
|
|
