Central subfield thickness only partially responsible for changes in acuity
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A post-hoc analysis of Protocol T from the DRCR Retina Network—which compared anti-VEGF compounds aflibercept, bevacizumab, and ranibizumab—has found changes in central subfield thickness account for only a small proportion of the total variation in visual acuity changes in DME patients. As such, changes in OCT should not be used as a guide to inform the physician or patient about changes in visual acuity after anti-VEGF treatment.
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