BioPharm International’s Biopharma Knowledge Resources Newsletter:
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BioPharm
January 23, 2018
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In This Issue

Build your biopharma development and manufacturing knowledge base with the latest whitepapers, application notes, posters, and other educational resources from biopharma industry suppliers.

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 Featured App Note

Fully Automated Digestion, Separation, and Analysis of the Human Prolactin Receptor Transmembrane Protein by LC-MS/MS

Shimadzu

Detection and quantification of peptides from transmembrane proteins is important for detection of biomarkers and new protein based drugs. This paper presents a fully automated online digestion and liquid chromatography-mass spectrometry-multiple reaction monitoring (LCMS MRM) analysis of two model transmembrane proteins, a method that improves reproducibility and decreases chances of contamination.

Downstream Processing

Removal of mAb Aggregates with TOYOPEARL® Sulfate-650F Resin

Tosoh Bioscience LLC

In this study, TOYOPEARL® Sulfate-650F, a strong cation exchange chromatography resin was used to capture and remove monoclonal antibody (mAb) aggregates and host cell proteins to improve the purity of the mAb eluate post-protein A in a single polishing step.

Manufacturing

Simple Steps to Speed Encapsulated Drug Development

Capsugel – Now a Lonza Company

In the pharmaceutical industry, speed to market is essential for gaining a competitive position. New encapsulation technologies now make it possible to streamline research and development activities, improve product development, and jump-start time to market.

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