In This Issue
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Build your biopharma development and manufacturing knowledge base with the latest whitepapers, application notes, posters, and other educational resources from biopharma industry suppliers.
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Featured App Note
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Sophia Kenrick and Daniel Some, Wyatt Technology Corp.
Measurement of the diffusion interaction parameter kD by DLS, combined with temperature ramps, provides comprehensive analysis of protein stability. Multiple formulations and candidates are readily screened in standard well plates.
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Downstream Processing
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Tosoh Bioscience LLC
A purified mAb sample, post-protein A purification step was loaded onto a Ca++Pure-HA (Hydroxyapatite) column. Using potassium phosphate buffer as a loading buffer and potassium chloride as an elution buffer, the mAb aggregate content was reduced from 6.6% to as low as 1.3%. |
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ANALYTICS
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Sonja Schneider, Agilent Technologies
Hydrophobic interaction chromatography (HIC) is used for the determination of drug-to-antibody ratio (DAR) of a cysteine-linked antibody drug conjugate (ADC).
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