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Antibody Affinity Extraction for HCP Analysis

Ken Hoffman and Eric Bishop, Cygnus Technologies, LLC

Antibody affinity extraction (AAE) is a superior alternative to 2D Western blot for demonstrating host cell protein (HCP) antibody coverage and reactivity to those HCPs that persist through the downstream purification process.

Effective Removal of Endotoxins with AEX Resin TOYOPEARL^® NH₂-750F

Tosoh Bioscience LLC

TOYOPEARL NH₂-750F resin is a salt-tolerant, anion exchange (AEX) resin ideal for the removal of endotoxins in monoclonal antibodies. It works in the presence of 150 mmol/L NaCl and a relatively low pH.