Build your biopharma development and manufacturing knowledge base with the latest whitepapers, application notes, posters, and other educational resources from biopharma industry suppliers.

SERS for Rapid Detection of the Low-Dose API in Xanax

Kristen Frano, Dawn Yang, B&W Tek

This paper demonstrates how a surface-enhanced Raman spectroscopy (SERS)-based approach can be used to quickly verify the presence of low-dose APIs in tablets for anti-counterfeiting in the pharmaceutical industry.

Purifying Humira Biosimilar with Mixed-Mode Resins

Randy Drevland, Chelsea Pratt, Payal Khandelwal, Laura Moriarty, Elizabeth Jordan Dreskin, Bio-Rad Laboratories

Remove the bottleneck of purifying therapeutic monoclonal antibodies (mAbs) for screening. Save time and increase productivity by automating multicolumn purification during drug development on the NGC Chromatography System.

Effective Removal of mAb Aggregate Using Ca⁺⁺Pure-HA® (Hydroxyapatite) Media with Potassium Salts

Tosoh Bioscience LLC

A purified monoclonal antibody (mAb) sample, post-protein A purification step was loaded onto a Ca⁺⁺Pure-HA (Hydroxyapatite) column. Using potassium phosphate buffer as a loading buffer and potassium chloride as an elution buffer, the mAb aggregate content was reduced from 6.6% to as low as 1.3%.

Purification of Large Biomolecules with New Anion Exchange (AEX) Resin

Bio-Rad

IgM antibodies are one of the fastest growing groups of diagnostic and therapeutic candidates. Unlike IgGs, IgMs cannot be purified by affinity chromatography due to their physiochemical properties. The large size of IgMs presents a purification challenge. A new AEX resin has been developed to overcome the multiple issues faced when purifying large biomolecules.