Pharmaceutical Technology EPR Monthly Issue:
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Pharm Tech
August 15, 2018
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PRODUCTION TRENDS

Considering Twin-Screw Extruders for Continuous Mixing and Granulation

A twin-screw extruder can be used as a continuous wet granulator or as a continuous mixer for a wet gelatin mass.
/ read more /

Exploring a Modern Control Strategy for Wurster Coating

A process control system based on PAT can compensate for variations in particle size, resulting in more consistent coating thickness.
/ read more /


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FROM THE ARCHIVE: GRANULATION

Scaling Up a Continuous Granulation Process

Continuous twin-screw granulation offers several options for increasing production scale.
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Direct Compression versus Granulation

Tablet manufacturers can use three different processing technologies: direct compression, dry granulation and wet granulation.
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Granulation Method and Process Monitoring Matter

The characteristics of tableted solid dosage drugs often depend on the granulation process, so selecting the most appropriate granulation technique and monitoring the process are crucial.
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Monitoring Fluid-Bed Granulation and Milling Processes In-Line with Real-Time Imaging

This study assessed the ability to measure particle size distributions under static (offline) and dynamic (on-line) conditions for milled and fluidized particles.
/ read more /

IN THE NEWS

FDA Forms Drug Shortages Task Force

FDA Commissioner, Scott Gottlieb, announced formation of a new, drug shortages task force and efforts to advance long-term solutions to prevent shortages.
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PACKAGING

Serialization: Scaling Down for the Final Stretch

Vendors are offering template-based models and direct data-filing services to help smaller companies meet imminent deadlines.
/ read more /

More Packaging

Editor's Picks

Capsule Filler for Medium-Sized Batches Controls Individual Process Steps

Fette Compacting’s FEC20 capsule filler for medium-sized batches is a smaller version of its FEC40 machine.
/ read more /

Particle Sizer for Dry and Wet Measurement

The Analysette 28 ImageSizer from Fritsch provides analysis of particle shape and size for dry measurement of powders and bulk solids and wet measurement of suspensions and emulsions.
/ read more /

Equipment Showcase

Leistritz manufactures twin screw extruders and systems for continuous mixing/devolatilization of API's with excipients. Lab scale and production scale equipment is available, and applications include melt extrusion and granulation. A variety of upstream and downstream equipment is available. Services include a process NJ development laboratory and ongoing training/workshops.
/ See this link for more info /

To meet production goals, you need to ensure that products are delivered to specification and documentation and compliance requirements are met. Reducing excessive work in process, eliminating the inefficient use of resources, and better management of your operations will lead to increased profitability for your organization. Emerson's Syncade manufacturing execution system (MES) helps you gain visibility and improve manufacturing processes to meet production goals.
/ Read more /

World's Fastest Capsule Filling Machine
Fette Compacting's new FEC40 Capsule Filler produces up to 400,000 capsules/hr – nearly twice that of any other capsule filler. This dramatically elevated output is accomplished in a remarkably small footprint, making machine reconfiguration due to floor space unnecessary. The high performance-to-footprint ratio is due to Fette Compacting's patented Duplex Concept, which utilizes a mirrored capsule filling process and double-sided discharge. / Read more /


UPCOMING WEBCAST

Part 2: A Collaborative Approach for Successful Method Transfers and Routine Quality Control Batch Release Testing
Tuesday, August 21, 2018 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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ON DEMAND WEBCASTS

How Protocol Design Drives Comparator Sourcing Cost, Timelines, Complexity, and Risk
On Demand
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Building a Faster, More Flexible Biologic Development Process for Targeted Therapies
On Demand
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How Well Should You Understand Your Crystallization Process (and Solid-State Properties)?
On Demand
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Best Practices for Highly Potent API (HPAPI) Development and Manufacturing
On Demand
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EVENTS

Cleaning Validation

Aug. 21–23, 2018 | Philadelphia, PA


CPhI Worldwide 2018

Oct. 9–11, 2018 | Madrid, Spain


Healthcare Packaging EXPO

Oct. 14–17, 2018 | Chicago, IL


more events

eBOOK

Biologics and Sterile Drug Manufacturing 2018 eBook

This eBook covers novel technologies for the formulation, manufacture, purification, and delivery of sterile small- and large-molecule drugs, including single-use systems, facilities and equipment, contamination issues, process analytics, and process modeling.


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