Pharmaceutical Technology’s Pharma Knowledge Resources Newsletter: Having trouble viewing this e-mail? Click here   Method Transfer from an Agilent 1260 Infinity LC to 1260 Inifinity II This application note shows method transfer from an Agilent 1260 Infinity LC to an Agilent 1260 Infinity II LC for the analysis of paracetamol and its impurities. Heart-Cut 2D-LC/MS approach for pharmaceutical impurity identification A heart-cut 2D LC–MS method for the identification of a close eluting impurity observed in Duloxetine drug substance using a non-MS compatible reverse-phase LC method. USP 467 Analysis of Residual Solvents An analysis of residual solvents according to USP 467 was evaluated on an Agilent Intuvo system equipped with a headspace sampler. Analysis of E&L Metals in Plastic Materials of Construction per USP <661.1> A complete solution for quantitation of extractable and leachable metals in plastic materials of construction, as per the USP <661.1> acid extraction procedure Automated Targeted Screening of Leachables in Pharmaceutical QC Labs Organic nonvolatile leachables from ophthalmic drug products were identified and quantified using an Agilent LC/MSD XT based on single quadrupole technology. E&L Analysis of Compounds From Plastic Intravenous Bag Sets Using GC/MSD Two Agilent 5977A Series GC–MSD Systems were used for the analysis of extractable and leachable compounds in plastic IV bag sets. Analysis of E&L Compounds using Low-Energy GC/Q-TOF A novel tool to study E&L compounds with enhanced flexibility and confidence using a high-resolution accurate mass GC–Q-TOF with a low-energy EI capable ion source. Determining Elemental Impurities Using USP/ICH Methodology and ICP-MS Agilent 7800 ICP-MS, using organic solvent preparation proved ideal for determination of elemental impurities in pharma ingredients per ICH Q3D and USP <232/233>. Elemental Impurities in Aspirin; Validating USP <232>/<233> and ICH Q3D The Agilent 5110 ICP-OES easily meets the requirements for determining elemental impurities according to the ICH Q3D and USP <232> and <233> procedures. Automated and Sensitive HCP Analysis An HCP analysis workflow using the Agilent AssayMAP Bravo platform for automated sample preparation and the Agilent 6545XT AdvanceBio LC/Q-TOF for LC-MS/MS analysis.