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Bioreactor Automation Driven by Real-Time Sensing: Enhancing Productivity Through Accurate, Efficient Glucose Control
Automation is a key trend driving improvements in manufacturing, especially for biopharmaceutical production. One big challenge is the integration of systems for effective automation. In-line sensors in mammalian cell culture can be used to monitor biomass production, key media nutrients, or metabolism indicators. Spectrophotometric techniques such as near-infrared (NIR) and Raman technology are used to quantitate and correlate spectroscopic data with precise chemical signatures. As a result, monitoring of glucose concentrations and lactate in real time is becoming more common, reducing the need for off-line analysis and enabling the automated delivery of media supplements as required.
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