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In our June issue:
COLUMNS
LC Troubleshooting
Recovering from a COVID-19 Shutdown: Tips and Tricks for Starting Up, Part I
Dwight R. Stoll and Tony Taylor
When you restart liquid chromatography (LC) instrumentation that was idle during the COVID-19 shutdown, you need to follow a systematic approach. Otherwise, problems may appear in days or weeks following startup.
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Perspectives in Modern HPLC
Stability Studies and Testing of Pharmaceuticals: An Overview
Kim Huynh-Ba and Michael W. Dong
Determining product shelf life is a regulatory requirement for pharmaceuticals and many other regulated consumer products. In this comprehensive overview of stability studies and testing, we summarize current regulatory requirements, share industry practices for forced degradation, and explain approaches for reduced testing and data evaluation to expedite stability study timelines.
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Get in the Driver’s Seat: Guidance for Compliance with Vehicle Interior Air Quality Guidelines
Wednesday, June 17, 2020 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Focus on Biopharmaceutical Analysis
Multidimensional Separation Techniques for Characterization of Biotherapeutics
Anurag S. Rathore, Ramesh Kumar, and Ira S. Krull
Multidimensional separations, in which two or more separation methods are coupled, are a valuable analytical tool for higher peak capacity and improved selectivity for the analysis of complex samples like biotherapeutics.
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Streamline Routine Volatiles Analysis—Filling the Awkward Gap Between GC and LC
Part 3. Faster, Simpler Method Validation with Direct MS, in Compliance with Regulatory Guidelines
Monday, June 22, 2020 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST
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Fundamentals
Troubleshooting Gas Chromatography: Reduced Peak Size (Loss of Sensitivity)
Tony Taylor
A new method, the RGB (red-green-blue) additive color model, provides a holistic evaluation of the effectiveness, safety, sustainability, and practicality of an analytical method.
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Feature Article
Are You Controlling Peak Integration to Ensure Data Integrity?
R.D. McDowall
Chromatography data systems (CDS) have been at the center of multiple FDA 483 citations and warning letters, with an emphasis on peak integration and interpretation of chromatograms. Here, we review the issues associated with ensuring compliance when performing peak integration.
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20 Steps to a Reliable Mobile Phase
Thursday, June 25, 2020 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST
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The Application Notebook |
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Tips and Tricks to Improve Essential Lab Practices: Weighing, Pipetting, and Using Volumetric Glassware
Tuesday, June 30, 2020 at 11am EDT|8am PDT|4pm BST|5pm CEST
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Recent Developments in LC Column Technology
A supplement to the June regular issue
Challenges in Obtaining Relevant Information from One- and Two-Dimensional LC Experiments
B.W.J. Pirok and J.A. Westerhuis
To address the quest for greater separation power, the chromatographic community developed comprehensive two-dimensional liquid chromatography (LCxLC). But even with LCxLC, it can still be challenging to analyze highly complex samples and obtain accurate and correct information. In this article, opportunities for optimizing methods for extracting maximum information from one-dimensional (1D)-LC and two-dimensional (2D)-LC chromatographic data are explained.
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The Potential for Portable Capillary Liquid Chromatography
James P. Grinias
Is the desired goal of “shrinking down” capillary liquid chromatography (LC) from large laboratory systems to accurate portable field instruments realistic? This article explores recent progress in the miniaturization of LC components—such as capillary LC columns, micro- and nano-flow pumps, detectors, and other essential system components—and the future outlook for operating capillary LC instruments in remote settings.
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Biocompatible Microextraction Devices for Simple and Green Analysis of Complex Systems
Emanuela Gionfriddo
Pretreatment of complex samples remains a key step in the analytical workflow, critically impacting the overall accuracy of results. Pretreatment methods have been a challenge for food, biofluids, and environmental samples. Here, the development and evolution of biocompatible solid-phase microextraction (bio-SPME) as a sample pretreatment method are discussed for use in liquid chromatography and direct mass spectrometry applications.
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Boosting the Purification Process of Biopharmaceuticals by Means of Continuous Chromatography
Chiara De Luca, Simona Felletti, Giulio Lievore, Alessandro Buratti, Mattia Sponchioni, Alberto Cavazzini, Martina Catani, Marco Macis, Antonio Ricci, and Walter Cabri
Single-column (batch) chromatography, involving two or more successive single-column (batch) chromatographic steps, is a standard approach for purifying biopharmaceuticals. Step one, known as the capture step, is used to remove product-related impurities, and step two, the polishing step, is used to remove product-related impurities. Here we present and illustrate the advantages of continuous chromatography for these separations: capture simulated moving bed (captureSMB) for the capture step and multicolumn countercurrent solvent gradient purification (MCSGP) for polishing.
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| NEW WEBCASTS |
Faster, Simpler Method Validation with Direct MS, in Compliance with Regulatory Guidelines
Monday, Jun. 22, 2020 at 11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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20 Steps to a Reliable Mobile Phase
Thursday, Jun. 25, 2020 at 11am EDT | 8am PDT| 4pm BST | 5pm CEST
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Direct MS Simplifies Analysis of Challenging Compounds
Monday, Jul. 13, 2020 at 11 am EDT | 8 am PDT | 4 pm BST | 5 pm CEST
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| ON DEMAND WEBCASTS |
An In-Depth Look at Intact Biotherapeutic Characterization and Quantitation in Biological Matrices
On Demand
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Advances in Gas Chromatography for Separation of Challenging Analytes in the Pharmaceutical, Environmental, Cannabis, and Food Industries
On Demand
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How to Build a Cannabis Testing Laboratory
On Demand
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Dealing with a Volatile Relationship: Using Purge and Trap and GC–MS to Improve Volatile Organic Compound Workflows
On Demand
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Testing Nitrosamine Content in Pharmaceutical Products
On Demand
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